Rim1 and Rim2 Redundantly Determine Ca 2+ Channel Density and Readily-releasable Pool 2 Size at a Large Hindbrain Synapse 3 4 5
نویسندگان
چکیده
1 Laboratory of Synaptic Mechanisms, Brain-Mind Institute, School of Life Sciences, École 11 Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland 12 2 Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Lorry 13 Lokey SIM1 Building, 265 Campus Drive, Stanford University School of Medicine, Stanford, 14 CA 94305, USA 15 3 current address: 16 Y.H.: Biozentrum, Universität Basel, Basel, Switzerland. 17 N.B.: Institute of Animal Physiology & Department of Biology, Universität Erlangen-Nürnberg, 18 91058 Erlangen, Germany 19 P.K.: Department of Neurobiology, Harvard Medical School, Boston 02115, USA 20 21 Abbreviated title: Role of two RIM genes at the calyx of Held 22
منابع مشابه
RIM1 and RIM2 redundantly determine Ca channel density and readily releasable pool size at a large hindbrain synapse
Han Y, Babai N, Kaeser P, Südhof TC, Schneggenburger R. RIM1 and RIM2 redundantly determine Ca channel density and readily releasable pool size at a large hindbrain synapse. J Neurophysiol 113: 255–263, 2015. First published October 15, 2014; doi:10.1152/jn.00488.2014.—The localization and density of voltagegated Ca channels at active zones are essential for the amount and kinetics of transmitt...
متن کاملRIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.
The localization and density of voltage-gated Ca(2+) channels at active zones are essential for the amount and kinetics of transmitter release at synapses. RIM proteins are scaffolding proteins at the active zone that bind to several other presynaptic proteins, including voltage-gated Ca(2+) channel α-subunits. The long isoforms of RIM proteins, which contain NH2-terminal Rab3- and Munc13-inter...
متن کاملInteraction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.
OBJECTIVE Glucagon-like peptide-1 (GLP-1) rescues insulin secretory deficiency in type 2 diabetes partly via cAMP actions on exchange protein directly activated by cAMP (Epac2) and protein kinase A (PKA)-activated Rab3A-interacting molecule 2 (Rim2). We had reported that haplodeficient Munc13-1(+/-) mouse islet beta-cells exhibited reduced insulin secretion, causing glucose intolerance. Munc13-...
متن کاملRIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
At presynaptic active zones, neurotransmitter release is initiated by the opening of voltage-gated Ca²+ channels close to docked vesicles. The mechanisms that enrich Ca²+ channels at active zones are, however, largely unknown, possibly because of the limited presynaptic accessibility of most synapses. Here, we have established a Cre-lox based conditional knockout approach at a presynaptically a...
متن کاملSynaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the fast and slow phase of release, respectively, but does not change the size of the readily-releasable pool (RRP) of vesicles as measured by stimulati...
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تاریخ انتشار 2014